3 ms·

The Illuminating Geometry of Viruses

116 points by algui91 9y ago

noir-york 9y ago
Thanks for posting this! Super interesting
- algui91 9y ago
  Glad you liked it
blinry 9y ago
You might also enjoy Hamish Todd's (highly interactive) documentation on virus geometry: http://viruspatterns.com http://viruspatterns.com
tinix 9y ago
Mmmm... geometry. Resonance. So you take this known and documented knowledge of lipid mechanics[0], and apply that to geometry of pathogens. Very much like electroporation[1] but, with magnetic fields and RF instead of direct application of voltage. but try and research: "Mortal Oscillatory Rate" or "Raymond Rife" and be inundated with disinformation and BS. Resonance is not a new or strange concept, by any means, we have no shortage of study around these ideas, take nuclear magnetic resonance[2] for example. That's an example on a very low level, then we can see this with electroporation and ultrasonification techniques at a much higher level. It's very frustrating, however, as soon as it's applied in a field that is deemed derogatory to the pharmaceutical industry, suddenly it's woo and nonsense, apparently. We have documented evidence of these phenomenon at many levels, and the high and low level effects are pretty well understood, but as soon as it's applied in the middle somewhere, to actual pathogens, then, it's suddenly quackery, apparently. Meanwhile, at least we do have some research being done on these things and it's VERY promising: Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies[3] Destruction of bacterial spores by phenomenally high efficiency non-contact ultrasonic transducers[4] System for Cleansing Organisms from Water[5] I think most of the claims of quackery are just a knee-jerk reaction and it leads to throwing the baby out with the bath water; just because some asshats have made fake devices to exploit vulnerable people doesn't mean the technology they claimed to use is fake or nonsense. [0] https://en.wikipedia.org/wiki/Lipid_bilayer_mechanics https://en.wikipedia.org/wiki/Lipid_bilayer_mechanics [1] https://en.wikipedia.org/wiki/Irreversible_electroporation https://en.wikipedia.org/wiki/Irreversible_electroporation [2] https://en.wikipedia.org/wiki/Nuclear_Magnetic_Resonance https://en.wikipedia.org/wiki/Nuclear_Magnetic_Resonance [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845545/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845545/ [4] https://link.springer.com/article/10.1007/s10019-002-0214-2 https://link.springer.com/article/10.1007/s10019-002-0214-2 [5] https://www.google.com/patents/US20140202961 https://www.google.com/patents/US20140202961
- c3534l 9y ago
  > System for Cleansing Organisms from Water[5] Oh great, another new age "cleanse." /jk
- subroutine 9y ago
  What are you going on about? Vibrations or something? What does that have to do with this article, about how mathematicians helped solve the minimal genetic information necessary to fit inside of, and encode for, the construction of ostensibly complex geometric structures of viral capsids.
  - tinix 9y ago
    I don't know how to make it much simpler, but I'll try to ELI5 for you. Geometry has a direct relationship to resonance[0]. If you can target the specific resonance frequency of the capsid, you can destroy it with a wave form. If you break the capsid, the virus will not survive. Resonance can be induced in many ways, such as with ultrasound[1], microwaves[2], magnetic/dielectric fields[3], light[4][5], etc... Obviously, this isn't fool-proof, as resonance can also actually assist viruses with permeating cell membranes[6]. However, these concepts can be applied to many areas of biosciences. We know magnetic fields can also disrupt cancer[7]. [0]https://www.nature.com/articles/srep18030 https://www.nature.com/articles/srep18030 Resonances in Physics and Geometry [1] http://pubmedcentralcanada.ca/pmcc/articles/PMC183525/pdf/aem00060-0219.pdf http://pubmedcentralcanada.ca/pmcc/articles/PMC183525/pdf/ae... Quantitative Assessment of the Germicidal Efficacy of Ultrasonic Energy [2] http://www.ams.org/notices/199903/zworski.pdf http://www.ams.org/notices/199903/zworski.pdf Efficient Structure Resonance Energy Transfer from Microwaves to Confined Acoustic Vibrations in Viruses [3] https://www.google.com/patents/US4524079 https://www.google.com/patents/US4524079 Deactivation of microorganisms by an oscillating magnetic field [4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171215/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171215/ Ultrashort pulsed laser treatment inactivates viruses by inhibiting viral replication and transcription in the host nucleus [5] https://asu.pure.elsevier.com/en/publications/selective-inactivation-of-human-immunodeficiency-virus-with-an-ul https://asu.pure.elsevier.com/en/publications/selective-inac... Selective destruction of viruses with ultrashort pulsed lasers [6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189159/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189159/ Effect of ultrasound on herpes simplex virus infection in cell culture [7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155400/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155400/ Effect of Magnetic Fields on Tumor Growth and Viability
dnautics 9y ago
Also interesting: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009423 http://journals.plos.org/plosone/article?id=10.1371/journal....

116 points by algui91 9y ago

noir-york 9y ago

Thanks for posting this! Super interesting

algui91 9y ago
Glad you liked it

blinry 9y ago

You might also enjoy Hamish Todd's (highly interactive) documentation on virus geometry: http://viruspatterns.com http://viruspatterns.com

tinix 9y ago

Mmmm... geometry. Resonance. So you take this known and documented knowledge of lipid mechanics[0], and apply that to geometry of pathogens. Very much like electroporation[1] but, with magnetic fields and RF instead of direct application of voltage. but try and research: "Mortal Oscillatory Rate" or "Raymond Rife" and be inundated with disinformation and BS. Resonance is not a new or strange concept, by any means, we have no shortage of study around these ideas, take nuclear magnetic resonance[2] for example. That's an example on a very low level, then we can see this with electroporation and ultrasonification techniques at a much higher level. It's very frustrating, however, as soon as it's applied in a field that is deemed derogatory to the pharmaceutical industry, suddenly it's woo and nonsense, apparently. We have documented evidence of these phenomenon at many levels, and the high and low level effects are pretty well understood, but as soon as it's applied in the middle somewhere, to actual pathogens, then, it's suddenly quackery, apparently. Meanwhile, at least we do have some research being done on these things and it's VERY promising: Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies[3] Destruction of bacterial spores by phenomenally high efficiency non-contact ultrasonic transducers[4] System for Cleansing Organisms from Water[5] I think most of the claims of quackery are just a knee-jerk reaction and it leads to throwing the baby out with the bath water; just because some asshats have made fake devices to exploit vulnerable people doesn't mean the technology they claimed to use is fake or nonsense. [0] https://en.wikipedia.org/wiki/Lipid_bilayer_mechanics https://en.wikipedia.org/wiki/Lipid_bilayer_mechanics [1] https://en.wikipedia.org/wiki/Irreversible_electroporation https://en.wikipedia.org/wiki/Irreversible_electroporation [2] https://en.wikipedia.org/wiki/Nuclear_Magnetic_Resonance https://en.wikipedia.org/wiki/Nuclear_Magnetic_Resonance [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845545/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845545/ [4] https://link.springer.com/article/10.1007/s10019-002-0214-2 https://link.springer.com/article/10.1007/s10019-002-0214-2 [5] https://www.google.com/patents/US20140202961 https://www.google.com/patents/US20140202961

c3534l 9y ago
> System for Cleansing Organisms from Water[5] Oh great, another new age "cleanse." /jk
subroutine 9y ago
What are you going on about? Vibrations or something? What does that have to do with this article, about how mathematicians helped solve the minimal genetic information necessary to fit inside of, and encode for, the construction of ostensibly complex geometric structures of viral capsids.
- tinix 9y ago
  I don't know how to make it much simpler, but I'll try to ELI5 for you. Geometry has a direct relationship to resonance[0]. If you can target the specific resonance frequency of the capsid, you can destroy it with a wave form. If you break the capsid, the virus will not survive. Resonance can be induced in many ways, such as with ultrasound[1], microwaves[2], magnetic/dielectric fields[3], light[4][5], etc... Obviously, this isn't fool-proof, as resonance can also actually assist viruses with permeating cell membranes[6]. However, these concepts can be applied to many areas of biosciences. We know magnetic fields can also disrupt cancer[7]. [0]https://www.nature.com/articles/srep18030 https://www.nature.com/articles/srep18030 Resonances in Physics and Geometry [1] http://pubmedcentralcanada.ca/pmcc/articles/PMC183525/pdf/aem00060-0219.pdf http://pubmedcentralcanada.ca/pmcc/articles/PMC183525/pdf/ae... Quantitative Assessment of the Germicidal Efficacy of Ultrasonic Energy [2] http://www.ams.org/notices/199903/zworski.pdf http://www.ams.org/notices/199903/zworski.pdf Efficient Structure Resonance Energy Transfer from Microwaves to Confined Acoustic Vibrations in Viruses [3] https://www.google.com/patents/US4524079 https://www.google.com/patents/US4524079 Deactivation of microorganisms by an oscillating magnetic field [4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171215/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171215/ Ultrashort pulsed laser treatment inactivates viruses by inhibiting viral replication and transcription in the host nucleus [5] https://asu.pure.elsevier.com/en/publications/selective-inactivation-of-human-immunodeficiency-virus-with-an-ul https://asu.pure.elsevier.com/en/publications/selective-inac... Selective destruction of viruses with ultrashort pulsed lasers [6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189159/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189159/ Effect of ultrasound on herpes simplex virus infection in cell culture [7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155400/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155400/ Effect of Magnetic Fields on Tumor Growth and Viability

dnautics 9y ago

Also interesting: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009423 http://journals.plos.org/plosone/article?id=10.1371/journal....