> At some point you'll be giving someone a dose so high they are guaranteed to die. This is not how opioid pharmacology works. Tolerance to the desired effects

> At some point you'll be giving someone a dose so high they are guaranteed to die. This is not how opioid pharmacology works. Tolerance to the desired effects (analgesia) increases but so does tolerance to the problematic effects (respiratory depression). Opioid use -- even chronic and long-term use -- is not a death sentence. The phenomenon of so many opioid-related deaths referred to as the "opioid epidemic" is an extremely recent one (compared to the timescale that humans have been using opiates for pain relief) and is a product of drug policy/enforcement, not of the inherent evil of opioids.