4 ms·

"Berkowitz picks up a box of sodium bicarbonate, which is crucial for heart surgery and to treat certain overdoses. It’s being rationed because there’s so littl

"Berkowitz picks up a box of sodium bicarbonate, which is crucial for heart surgery and to treat certain overdoses. It’s being rationed because there’s so little available." Huh? US hospitals have a shortage of Baking Soda?

detaro 9y ago
Yes. One of 2 (or 3?) manufacturers in the US making it as a medical product had manufacturing issues, so there isn't enough of it that's cleared for medical use available. EDIT: https://www.usatoday.com/story/money/2017/05/31/how-baking-soda-shortage-became-health-care-crisis/102320494/ https://www.usatoday.com/story/money/2017/05/31/how-baking-s...
doctoring 9y ago
Oh yes... it's a pain in the ass. Recently in the news, too [1]. There weren't many days where the hospitals I've worked at weren't short on something. (And these are like, big name academic medical centers in big U.S. cities.) I've run into a shortage of normal saline before. Yes... salt water. Sometimes hospitals will even stockpile basic supplies to keep from running into shortages... which only makes the whole situation worse. It causes a lot of patient harm, even if it's usually not catastrophic because we usually have redundant meds. Recently my hospital was out of a common, generic, cheap antibiotic. For many infections in many patients, this meant we had to switch to the second-line drug -- which was more expensive, had more side effects, and was less effective against the bug. This type of thing happens to chemo drugs, to drugs you give after a heart attack, to drugs you need for planned surgeries or procedures. I don't know how to solve this. Less regulation? More regulation? Subsidies for manufacturers of essential medications / supplies? I mean, normal saline is already ridiculously expensive enough [2]. For more reading: http://news.medill.northwestern.edu/chicago/hospital-drug-shortages-what-is-really-causing-them/ http://news.medill.northwestern.edu/chicago/hospital-drug-sh... [1]: https://www.nytimes.com/2017/05/21/health/sodium-bicarbonate-solution-critical-shortage-hospitals.html https://www.nytimes.com/2017/05/21/health/sodium-bicarbonate... [2]: http://www.nytimes.com/2013/08/27/health/exploring-salines-secret-costs.html http://www.nytimes.com/2013/08/27/health/exploring-salines-s...
- valuearb 9y ago
  Remove patent protection for any drugs that are in shortage.
  - mandevil 9y ago
    Do you honestly think that baking soda is in shortage because of patent restrictions? The US drug system is messed up, but not that messed up. They are in shortage because it takes a long time (six-ish months) to certify a factory as producing something safe for consumption[1], and in the normal course of things, there is very little point in setting up a second line to produce medical grade sodium bicarb- no company is going to show a profit from it. So you get one place producing the national supply, just large enough to handle the normal demand. Then they have a problem (in this case, Pfizer was unable to source the glass ampules) and now there is no production. [1]: And with good reason. Producing mass quantities of sterile, consistent, things with the correct amount of material is hard. Source: wife is a pharmacist tasked with doing her hospitals contingency plans on bicarb.
    - valuearb 9y ago
      This article isn't just about baking soda. If society freely allows you the massive competitive barrier of a patent to ensure your riches, you should also have some obligations to society as part of the contract.
      - mandevil 9y ago
        The article isn't, but most of the really egregious price increases we've observed (e.g. epipens, all the drugs that Martin Shkreli bought, etc.) have likewise not been on drugs under patent protection. In point of fact, most drug companies have faced what are called patent cliffs, where due to troubles in the R&D pipeline[1] drugs lose patent protections far faster than new drugs come online to replace them. While this is probably bad for society overall- we really want lots of new drugs getting discovered and making us healthier![2]- it means that patents protect smaller and smaller portions of the overall drug market. IOW, playing games with them has less and less overall value as the years have progressed. Need to find new levers to have influence on this market. [1]: A totally different subject with a lot of theories as to why, but not much in the way of solid evidence. [2]: Yes, the 1k USD/pill Solvadi is amazingly expensive. By the same token, it actually works, and cures you after three months. This is the sort of medicine that improves humanity, even at that price. There are plenty of other drugs (especially cancer drugs that extend lifespan by averages of <4 months) that do not improve humanity, but Solvadi does. It just costs a ton.
pilsetnieks 9y ago
Medical grade baking soda, yes: https://arstechnica.com/science/2017/05/baking-soda-shortage-has-hospitals-frantic-delaying-treatments-and-surgeries/ https://arstechnica.com/science/2017/05/baking-soda-shortage... You can't just take a box from the baking supplies shelf in Walmart.
- AstralStorm 9y ago
  You could but shouldn't outside of battlefield or other critical conditions. Direct solutions have been used some hundred years ago, prepared on place by a chemist. (They tended to use better than food grade, but not much better.)
refurb 9y ago
It's an injectable product. That's not easy to manufacture at all and has high capital costs. You need to make sure it's sterile and remove any pyrogens. Manufacturing injectables requires a much more strict adherence to quality than oral products.
rcdmd 9y ago
Yes, and it's even more bizarre when you realize what we need it for-- critically ill patients who are so acidotic that drugs like epinephrine (adrenaline) don't work. Bicarb reverses that acidosis, it doesn't cure it, but it does make it so your epi and other drugs have a chance to work. The main alternative is sodium acetate, which depresses heart function, causes low blood pressure and reduces respiratory drive.

detaro 9y ago

Yes. One of 2 (or 3?) manufacturers in the US making it as a medical product had manufacturing issues, so there isn't enough of it that's cleared for medical use available. EDIT: https://www.usatoday.com/story/money/2017/05/31/how-baking-soda-shortage-became-health-care-crisis/102320494/ https://www.usatoday.com/story/money/2017/05/31/how-baking-s...

doctoring 9y ago

Oh yes... it's a pain in the ass. Recently in the news, too [1]. There weren't many days where the hospitals I've worked at weren't short on something. (And these are like, big name academic medical centers in big U.S. cities.) I've run into a shortage of normal saline before. Yes... salt water. Sometimes hospitals will even stockpile basic supplies to keep from running into shortages... which only makes the whole situation worse. It causes a lot of patient harm, even if it's usually not catastrophic because we usually have redundant meds. Recently my hospital was out of a common, generic, cheap antibiotic. For many infections in many patients, this meant we had to switch to the second-line drug -- which was more expensive, had more side effects, and was less effective against the bug. This type of thing happens to chemo drugs, to drugs you give after a heart attack, to drugs you need for planned surgeries or procedures. I don't know how to solve this. Less regulation? More regulation? Subsidies for manufacturers of essential medications / supplies? I mean, normal saline is already ridiculously expensive enough [2]. For more reading: http://news.medill.northwestern.edu/chicago/hospital-drug-shortages-what-is-really-causing-them/ http://news.medill.northwestern.edu/chicago/hospital-drug-sh... [1]: https://www.nytimes.com/2017/05/21/health/sodium-bicarbonate-solution-critical-shortage-hospitals.html https://www.nytimes.com/2017/05/21/health/sodium-bicarbonate... [2]: http://www.nytimes.com/2013/08/27/health/exploring-salines-secret-costs.html http://www.nytimes.com/2013/08/27/health/exploring-salines-s...

valuearb 9y ago
Remove patent protection for any drugs that are in shortage.
- mandevil 9y ago
  Do you honestly think that baking soda is in shortage because of patent restrictions? The US drug system is messed up, but not that messed up. They are in shortage because it takes a long time (six-ish months) to certify a factory as producing something safe for consumption[1], and in the normal course of things, there is very little point in setting up a second line to produce medical grade sodium bicarb- no company is going to show a profit from it. So you get one place producing the national supply, just large enough to handle the normal demand. Then they have a problem (in this case, Pfizer was unable to source the glass ampules) and now there is no production. [1]: And with good reason. Producing mass quantities of sterile, consistent, things with the correct amount of material is hard. Source: wife is a pharmacist tasked with doing her hospitals contingency plans on bicarb.
  - valuearb 9y ago
    This article isn't just about baking soda. If society freely allows you the massive competitive barrier of a patent to ensure your riches, you should also have some obligations to society as part of the contract.
    - mandevil 9y ago
      The article isn't, but most of the really egregious price increases we've observed (e.g. epipens, all the drugs that Martin Shkreli bought, etc.) have likewise not been on drugs under patent protection. In point of fact, most drug companies have faced what are called patent cliffs, where due to troubles in the R&D pipeline[1] drugs lose patent protections far faster than new drugs come online to replace them. While this is probably bad for society overall- we really want lots of new drugs getting discovered and making us healthier![2]- it means that patents protect smaller and smaller portions of the overall drug market. IOW, playing games with them has less and less overall value as the years have progressed. Need to find new levers to have influence on this market. [1]: A totally different subject with a lot of theories as to why, but not much in the way of solid evidence. [2]: Yes, the 1k USD/pill Solvadi is amazingly expensive. By the same token, it actually works, and cures you after three months. This is the sort of medicine that improves humanity, even at that price. There are plenty of other drugs (especially cancer drugs that extend lifespan by averages of <4 months) that do not improve humanity, but Solvadi does. It just costs a ton.

pilsetnieks 9y ago

Medical grade baking soda, yes: https://arstechnica.com/science/2017/05/baking-soda-shortage-has-hospitals-frantic-delaying-treatments-and-surgeries/ https://arstechnica.com/science/2017/05/baking-soda-shortage... You can't just take a box from the baking supplies shelf in Walmart.

AstralStorm 9y ago
You could but shouldn't outside of battlefield or other critical conditions. Direct solutions have been used some hundred years ago, prepared on place by a chemist. (They tended to use better than food grade, but not much better.)

refurb 9y ago

It's an injectable product. That's not easy to manufacture at all and has high capital costs. You need to make sure it's sterile and remove any pyrogens. Manufacturing injectables requires a much more strict adherence to quality than oral products.

rcdmd 9y ago

Yes, and it's even more bizarre when you realize what we need it for-- critically ill patients who are so acidotic that drugs like epinephrine (adrenaline) don't work. Bicarb reverses that acidosis, it doesn't cure it, but it does make it so your epi and other drugs have a chance to work. The main alternative is sodium acetate, which depresses heart function, causes low blood pressure and reduces respiratory drive.