Again, this is hard to answer in the abstract but for example, I see no issue with someone, who is an artist, getting an O-1 as an entrepreneur but as part of h

Again, this is hard to answer in the abstract but for example, I see no issue with someone, who is an artist, getting an O-1 as an entrepreneur but as part of his or her job duties, doing artwork - but the artwork needs to be for the US company in your capacity as an employee of that company.