Check out the "Regulation" paragraph in wiki: https://en.wikipedia.org/wiki/TP53#Regulation https://en.wikipedia.org/wiki/TP53#Regulation But in short, no, the

Check out the "Regulation" paragraph in wiki: https://en.wikipedia.org/wiki/TP53#Regulation https://en.wikipedia.org/wiki/TP53#Regulation But in short, no, there's not a simple heuristic. As most often the case in the cell, it's a finely tuned balance of several pathways, which tips in one direction or the other depending on the environment and all the other pathways in the cell.