3 ms·
TP53 is activated by phosphorylation (i.e. the addition of a phosphoryl group to the enzyme). The enzymes which phosphorylate TP53 in turn respond to several ty
by folli 9y ago
TP53 is activated by phosphorylation (i.e. the addition of a phosphoryl group to the enzyme). The enzymes which phosphorylate TP53 in turn respond to several types of stresses (e.g oxidation, membrane damage, heat) and a cascade of checkpoints that respond to different kinds of DNA damages.
Furthermore, there's an additional protein (HDM2) that binds to TP53 in healthy cells and deactivates TP53.
- folli 9y agoCheck out the "Regulation" paragraph in wiki: https://en.wikipedia.org/wiki/TP53#Regulation https://en.wikipedia.org/wiki/TP53#Regulation But in short, no, there's not a simple heuristic. As most often the case in the cell, it's a finely tuned balance of several pathways, which tips in one direction or the other depending on the environment and all the other pathways in the cell.