I like both of them a lot for different reasons: If I build a more generic web application that will include most of their typical features I'd go with Django.

I like both of them a lot for different reasons: If I build a more generic web application that will include most of their typical features I'd go with Django. If it is more of an one purpose API type of project or solving a very domain specific problem it would be Flask. Django gets your out of the door quickly and there are extensions for anything I've ever needed, but it can get in your way later on. If you have to go against its opinions or if you need to actually understand what it does under the hood. E.g. file upload goes trough several hundreds of lines of code if I remember correctly. Most of it probably doesn't apply to your project, but you need to understand it anyway. Flask projects are also super quick for simple projects, but if it is something more elaborate you really have to spent the extra time setup the architecture accordingly from the get go, otherwise it very easily becomes a big unmaintainable mess. My experience is mostly b2b products and projects, so scalability is less of an issue for me.