3 ms·

Organophosphates are very nasty indeed, if you look at research into those with large exposures, farmers, sheep dipping in particular; http://www.walesonline.c

by tudorw 9y ago

Organophosphates are very nasty indeed, if you look at research into those with large exposures, farmers, sheep dipping in particular; http://www.walesonline.co.uk/news/wales-news/calls-hillsborough-style-inquiry-sheep-dip-9118546 http://www.walesonline.co.uk/news/wales-news/calls-hillsboro... https://www.theguardian.com/environment/2016/may/18/uk-government-criticised-for-ongoing-delay-in-farm-poisoning-case-sheep-dipping https://www.theguardian.com/environment/2016/may/18/uk-gover... or this; "The present findings suggest OP pesticides are more harmful than previously thought, even at low levels of exposure." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042861/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042861/ Then there is the Gulf War Syndrome which has been associated to high levels of insecticide use; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1319191/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1319191/ and this more recently, 'Pesticides: an update of human exposure and toxicity' " A huge body of evidence exists on the possible role of pesticide exposures in the elevated incidence of human diseases such as cancers, Alzheimer, Parkinson, amyotrophic lateral sclerosis, asthma, bronchitis, infertility, birth defects, attention deficit hyperactivity disorder, autism, diabetes, and obesity. Most of the disorders are induced by insecticides and herbicides most notably organophosphorus, organochlorines, phenoxyacetic acids, and triazine compounds." https://link.springer.com/article/10.1007%2Fs00204-016-1849-x https://link.springer.com/article/10.1007%2Fs00204-016-1849-...

tudorw 9y ago
" In summary, young children may be especially vulnerable to pesticides because of the sensitivity of their developing organ systems combined with a limited ability to enzymatically detoxify these chemicals (13,123,126-131). According to the National Academy of Sciences (13), children's OP exposures are of special concern because "exposure to neurotoxic compounds at levels believed to be safe for adults could result in permanent loss of brain function if it occurred during the prenatal and early childhood period of brain development" (13). Because there is so little information available on the levels and routes of children's pesticide exposure, it is not feasible to conduct a risk assessment predicting the likelihood of adverse effects based on animal studies. Thus far, there are no data in children to support or refute the hypothesized health effects of chronic low-level pesticide exposure." https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.files/fileID/12739 https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/di... "We conclude that PT and PO are genotoxic, while DF shows mitogenic activity. An important finding of this study is that PT had higher genotoxic potential than PO, which warrants for further investigations to correctly evaluate the hazards of exposure to these chemicals." https://www.ncbi.nlm.nih.gov/pubmed/18418871 https://www.ncbi.nlm.nih.gov/pubmed/18418871 "Collectively, our results implicate gluconeogenesis as the key mechanism behind organophosphate-induced hyperglycemia, mediated by the organophosphate-degrading potential of gut microbiota. This study reveals the gut microbiome-mediated diabetogenic nature of organophosphates and hence that the usage of these insecticides should be reconsidered." https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1134-6 https://genomebiology.biomedcentral.com/articles/10.1186/s13...

by tudorw 9y ago

tudorw 9y ago

" In summary, young children may be especially vulnerable to pesticides because of the sensitivity of their developing organ systems combined with a limited ability to enzymatically detoxify these chemicals (13,123,126-131). According to the National Academy of Sciences (13), children's OP exposures are of special concern because "exposure to neurotoxic compounds at levels believed to be safe for adults could result in permanent loss of brain function if it occurred during the prenatal and early childhood period of brain development" (13). Because there is so little information available on the levels and routes of children's pesticide exposure, it is not feasible to conduct a risk assessment predicting the likelihood of adverse effects based on animal studies. Thus far, there are no data in children to support or refute the hypothesized health effects of chronic low-level pesticide exposure." https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.files/fileID/12739 https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/di... "We conclude that PT and PO are genotoxic, while DF shows mitogenic activity. An important finding of this study is that PT had higher genotoxic potential than PO, which warrants for further investigations to correctly evaluate the hazards of exposure to these chemicals." https://www.ncbi.nlm.nih.gov/pubmed/18418871 https://www.ncbi.nlm.nih.gov/pubmed/18418871 "Collectively, our results implicate gluconeogenesis as the key mechanism behind organophosphate-induced hyperglycemia, mediated by the organophosphate-degrading potential of gut microbiota. This study reveals the gut microbiome-mediated diabetogenic nature of organophosphates and hence that the usage of these insecticides should be reconsidered." https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1134-6 https://genomebiology.biomedcentral.com/articles/10.1186/s13...