4 ms·

Not outwards behavior but things that used to seem like such a big deal became trivial. Again anecdotal so don't put any stock in what I'm saying, I just found

Not outwards behavior but things that used to seem like such a big deal became trivial. Again anecdotal so don't put any stock in what I'm saying, I just found this to be interesting

ficklepickle 9y ago
Get a liver enzyme test. It's very hard on the liver, especially if you consume alcohol at the same time. Acetaminophen/paracetamol is not as harmless as most people think. It has wrecked many-a-liver.
- arcticbull 9y ago
  It's the #1 cause of liver failure in the United States. [1] [1] https://www.medpagetoday.com/psychiatry/depression/2233 https://www.medpagetoday.com/psychiatry/depression/2233
  - DanBC 9y ago
    But your link is talking about short term use - deliberate or accidental overdose. It's not talking about normal long term use. Paracetamol is commonly used in overdosing because people don't understand how dangerous an overdose is; they don't understand how painful a death from liver failure is; paracetamol is available off the shelf in large quantities; and many people have stocks of it in their homes. Indeed, your link suggests that long term use is not harmful: > But in an accompanying editorial, John G. O'Grady, M.D., of the Institute of Liver Studies at King's College Hospital in London cautioned that there's no need for panic, because acetaminophen-associated liver toxicity is uncommon, and the drug itself is not toxic. > "Measures to minimize acetaminophen hepatotoxicity are important but need to be considered in the context that the apparent scale of the problem is a reflection of the huge number of patients taking acetaminophen with good effects and in the absence of any adverse event," Dr. O'Grady wrote. > "Educational initiatives to highlight the range of preparations containing acetaminophen, together with reiteration of advice on maximum daily dosing, have potential benefits, especially with respect to unintentional overdosing," he added. And it says this: > The data suggest that consistent use of as little as 7.5 g/day of acetaminophen could lead to severe hepatic injury, Dr. Larson and colleagues wrote. That's a lot! The recommended dose on the box is 4 g per day - 4 doses of 1 g each, with 4 hours in between them.
brohoolio 9y ago
Sometimes those anecdotes are actually pretty revealing.

Not outwards behavior but things that used to seem like such a big deal became trivial. Again anecdotal so don't put any stock in what I'm saying, I just found this to be interesting

ficklepickle 9y ago

Get a liver enzyme test. It's very hard on the liver, especially if you consume alcohol at the same time. Acetaminophen/paracetamol is not as harmless as most people think. It has wrecked many-a-liver.

arcticbull 9y ago
It's the #1 cause of liver failure in the United States. [1] [1] https://www.medpagetoday.com/psychiatry/depression/2233 https://www.medpagetoday.com/psychiatry/depression/2233
- DanBC 9y ago
  But your link is talking about short term use - deliberate or accidental overdose. It's not talking about normal long term use. Paracetamol is commonly used in overdosing because people don't understand how dangerous an overdose is; they don't understand how painful a death from liver failure is; paracetamol is available off the shelf in large quantities; and many people have stocks of it in their homes. Indeed, your link suggests that long term use is not harmful: > But in an accompanying editorial, John G. O'Grady, M.D., of the Institute of Liver Studies at King's College Hospital in London cautioned that there's no need for panic, because acetaminophen-associated liver toxicity is uncommon, and the drug itself is not toxic. > "Measures to minimize acetaminophen hepatotoxicity are important but need to be considered in the context that the apparent scale of the problem is a reflection of the huge number of patients taking acetaminophen with good effects and in the absence of any adverse event," Dr. O'Grady wrote. > "Educational initiatives to highlight the range of preparations containing acetaminophen, together with reiteration of advice on maximum daily dosing, have potential benefits, especially with respect to unintentional overdosing," he added. And it says this: > The data suggest that consistent use of as little as 7.5 g/day of acetaminophen could lead to severe hepatic injury, Dr. Larson and colleagues wrote. That's a lot! The recommended dose on the box is 4 g per day - 4 doses of 1 g each, with 4 hours in between them.

brohoolio 9y ago

Sometimes those anecdotes are actually pretty revealing.