What did you read? Off-target changes are a major topic in gene editing approaches, and are universally reported. It is among the chief advantages for CRISPR.

What did you read? Off-target changes are a major topic in gene editing approaches, and are universally reported. It is among the chief advantages for CRISPR. There are hundreds of papers that discuss this, and dozens where it is the focus of the article. https://www.ncbi.nlm.nih.gov/pubmed/?term=crispr+specificity https://www.ncbi.nlm.nih.gov/pubmed/?term=crispr+specificity The specificity has been perfectly acceptable for many research purposes for several years now. The current issue is increasing this even more to be suitable for clinical applications. There are many strategies being considered.