4 ms·

Thanks for all the details. Are those atlas based methods applicable to standard T1 scans or require extras like T2 or flair? Are there available software imple

• SubiculumCode 9y ago
  the method is quite general and applies to any image type for which an appropriate atlas is available. It is simple to see why with a straightforward description of Multiatlas methods. Generally two steps are performed: Warping and Voing. Step 1. Warp. An atlas brain is spatially warped to match the subject's brain using affine, non-linear and diffeomorphic normalization tools (ANTs being one of the strongest contending registration spatial normalization programs). This warp maps the atlas's ROI onto the subject's brain, producing a candidate segmentation. This is done for each atlas, producing N candidate segmentations. Step 2. Vote. In its simplest form, candidate segmentations vote at each voxel for an ROI label, majority wins. This produces the finished segmentation. Advances in image registration and voting methods over the last decade have really made this the preferred method for accurate image registration. Unfortunately, sometimes good multi atlases are lacking. Historically, most published atlases are single atlases with an average or probability estimate at each voxel. There are some mutliatlases available for specific structures (e.g. hippocampus, see MAGeT comments above). I believe there are some multi ROI multi atlases now available. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691373/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691373/