This is too broad of a question. A tiring relationship is different from a dead end job which is different from eating the same sandwich at the same bar every

This is too broad of a question. A tiring relationship is different from a dead end job which is different from eating the same sandwich at the same bar every Thursday. If you want advice to broadly apply to any situation then the best I could think of is "you miss 100% of the shots you don't take". If there's a remote chance you can hit that shot, then take it. If you miss, figure out what went wrong and fix your situation from there. The best ability we have is to learn from other people mistakes. When that's not possible then learning from our own is typically good enough.