Some references for those who want to dig in. Will calorie restriction work in humans? http://dx.doi.org/10.18632/aging.100581 http://dx.doi.org/10.18632/aging

Some references for those who want to dig in. Will calorie restriction work in humans? http://dx.doi.org/10.18632/aging.100581 http://dx.doi.org/10.18632/aging.100581 Caloric restriction improves health and survival of rhesus monkeys https://dx.doi.org/10.1038/ncomms14063 https://dx.doi.org/10.1038/ncomms14063 In general, the consensus in the research community is that we shouldn't expect more than an additional ~5 years from the life-long practice of calorie restriction. The evolutionary argument is that the calorie restriction response evolved very early on in as a way to enhance fitness given seasonal famines. A season is a long time for a mouse, not so long for a human, so only the mouse evolves a very plastic lifespan. The practical argument is that 5-10 years is about the largest effect that could exist and still be hard to pull out from existing demographic data of restricted calorie intake in a bulletproof, rigorous way. Obviously any much larger effect would have been discovered in antiquity and be very well known and characterized by now. So that said about longevity, it is very clear that calorie restriction does better and more reliable things for health in ordinary humans in the short term of months and mid-term of few years than any presently available enhancement technology can replicate. A good deal of research into aging is focused on trying to recreate the calorie restriction response. So far this has consumed billions with little of practical use to show for it beyond increased knowledge of some thin slices of cellular biochemistry relating to nutrient sensing and energy metabolism. It has proven to be very hard and very expensive to get anywhere here. So calorie restriction itself is free and reliable in its effects. Everyone should give it a try. There are, however, far more important areas of aging research to direct funding to instead of trying to recreate this effect with pharmaceuticals. In an age in which meaningful rejuvenation is possible to create in the years ahead (see, for example, clearance of senescent cells, something that calorie restriction can only slightly achieve in a very tiny way, while drug candidates are managing 25-50% clearance) it seems just plain dumb to instead be chasing expensive, hard ways to only slightly slow down aging.