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Keep in mind there's also increasing evidence that HDL/LDL are symptoms, not causes of heart disease. Maybe the strongest is the failure of drugs that lower LDL
by semi-extrinsic 9y ago
Keep in mind there's also increasing evidence that HDL/LDL are symptoms, not causes of heart disease. Maybe the strongest is the failure of drugs that lower LDL and increase HDL - they don't make people better.
E.g. Eli Lilly's Evacetrapib: tested on 20k patients over 24 months, LDL down 30%, HDL up 125% - but zero difference in cardiovascular health outcomes. Needless to say it failed the trial and has been scrapped.
http://blogs.sciencemag.org/pipeline/archives/2017/05/18/now-this-is-a-drug-that-does-not-work http://blogs.sciencemag.org/pipeline/archives/2017/05/18/now...