" If a calorie is a calorie is a calorie, then we need to be able to explain why two people eating the same amount of calories per day, but one eating a high fa

" If a calorie is a calorie is a calorie, then we need to be able to explain why two people eating the same amount of calories per day, but one eating a high fat, low carb diet, and the other a low fat high carb diet see starkly different outcomes." Is there any evidence of that actually happening? Starkly different outcomes? Everything I've seen shows weight change to be pretty damn close on matched calorie diets with the macro mix not mattering much.