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From TFA: "Suramin works by inhibiting the signaling function of adenosine triphosphate (ATP), a nucleotide or small molecule produced by cellular mitochondria
by donquichotte 9y ago
From TFA: "Suramin works by inhibiting the signaling function of adenosine triphosphate (ATP), a nucleotide or small molecule produced by cellular mitochondria and released from the cell as a danger signal. When CDR is activated, the effect of extracellular ATP is similar to a warning siren that never stops. Suramin inhibits the binding of ATP and similar molecules to key purinergic receptors, according to Naviaux."
Are there any other substances out there that inhibit ATP signaling?
- Ntrails 9y agoI vaguely remember ATP from GCSE biology - and in my head it's related to energy production in cells... I'm curious whether that's merely poor memory or not
- bitexploder 9y agoWe could just Google this....but ATP adenosine triphosphate is the preferred energy source in the cellular energy cycle. A phosphate gets broken off when a cell uses it leaving ADP which is... Something something, I forget the rest. It's more expensive for the body to extract energy from ADP.
- epmaybe 9y agoIf you said "purinergic signaling" then yes. I think the one used quite often is clopidogrel (plavix) that inhibits the ADP receptor on platelets to prevent them from aggregating. As far as I know, though, the drugs studied that inhibit purinergic signaling have only been approved for anti-platelet purposes.