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Could you help explain how to interpret the list of effect sizes? I'm having trouble understanding what the numbers mean. For example, black hair is 0.00 herita
by Snackchez 9y ago
Could you help explain how to interpret the list of effect sizes? I'm having trouble understanding what the numbers mean. For example, black hair is 0.00 heritable. Does that mean one cannot inherit black hair? (Is this black in the sense of asiatic hair?)
- bagacrap 9y ago> However, if the GCTA estimate was ~0%, then that would imply one of three things: a) there is no genetic contribution, b) the genetic contribution is entirely in the form of genetic variants not included, or c) the genetic contribution is entirely in the form of non-additive effects such as epistasis/dominance
- Obi_Juan_Kenobi 9y agoThis isn't GxE heritability (i.e. genetics vs. environment), but rather a metric for how SNPs influence additive traits. It's best considered a lower bound to what we would normally consider heritability. In this case, it's not an additive, multi-factorial trait; it's epistatic. There's a 'black hair' gene that overrides whatever else is happening in your genome. This is often the case with color traits: a dark color overrides anything lighter. It's the classic example of dominance.