2. I get they are experimental musicians and composers chomping at the bit to finally play their finest arcane musique tintinnabulations. But they should first

2. I get they are experimental musicians and composers chomping at the bit to finally play their finest arcane musique tintinnabulations. But they should first try to provide simple, structured musical inputs (repetitive drum taps would be the best, or square waves of particular frequencies; but at the very least simple repetitive melodies). At least until they can determine if these neurons are reacting in any predictable way to the microelectrode inputs. In one of the videos it basically looks like they mic'd up a petri dish on stage with a bunch of avant garde musicians working their hardest. That's actually pretty hilarious. Anyway, they should hold off on that until after they figure out whether these 'trans' neurons can even hear them. 3. They should try to train these neurons. Instead of microarray dishes though, I'd use optogenetics. From my experience it's much easier to evoke predictable signals using fiber optical input. It would be best to pass their instruments through a computer program though, that translated their sounds into pulse frequencies known to induce synaptic potentiation or synaptic depression. Currently, they are just adding noise to an already noisy system. All that said, this is still a cool project. And FWIW, they are much better neuroscientists than I am a musician.