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What is it that you mean by a 'non-addictive' opioid? They're all roughly equivalent in their addictive potential. Even those that are used to treat addiction,
by _acme 9y ago
What is it that you mean by a 'non-addictive' opioid? They're all roughly equivalent in their addictive potential. Even those that are used to treat addiction, such as buprenorphine, cause physical and mental dependence.
- kortex 9y agoThere are a few ways to make opioids less addicting. The most common strategy is to slow down absorption rate, which reduces the conditioning associated with drug-taking behavior. This can be done mechanically (sustained release pills or polymers) or chemically ("tie" the active molecule with a deactivating group which the body hydrolyses) http://www.sciencedirect.com/science/article/pii/S1369702116000304 http://www.sciencedirect.com/science/article/pii/S1369702116...
- _acme 9y agoDo you mean to suggest that OxyContin (extended-release oxycodone) is less of a problem, or less addicting, than Percocet (instant release oxycodone + APAP)?