3 ms·
Tolerance generally does not affect the lethality of a drug.
by tantalor 10y ago
Tolerance generally does not affect the lethality of a drug.
- ceejayoz 10y agoHospice patients on morphine would strongly disagree. http://www.medscape.com/viewarticle/562216_3 http://www.medscape.com/viewarticle/562216_3 > Pharmacokinetic changes occur, for example, if the drug up-regulates the activity of a metabolic process that represents a major pathway for its elimination from the body. Enzyme induction results in a gradual reduction in plasma drug concentration while the daily opioid dose remains unchanged.
- trendia 10y agoThat's not entirely accurate in general. If the tolerance is the result of improved metablosim (as in alcoholism), then it could lead to decreased lethality.
- kerkeslager 10y agoThis isn't even the kind of claim that can be tested scientifically--there are too many different kinds of drugs. And I can think of many drugs where tolerance does affect lethality (opiates, alcohol). Where are you getting this information from?