4 ms·

"may have consumed about 470mg of caffeine in just under two hours" I find it hard to believe that caused a problem for a 200lb person. I'm 150 and drink more

"may have consumed about 470mg of caffeine in just under two hours" I find it hard to believe that caused a problem for a 200lb person. I'm 150 and drink more than that every morning and have for years (2/3rds or a full pot, big cup, it's gone pretty quickly--like 1.5 hours). I also pretty regularly will drink 3 or 4 (150mg/ea) venti lattes in a couple of hours. As far as I can tell, I'm still alive.

ceejayoz 9y ago
https://en.wikipedia.org/wiki/Drug_tolerance https://en.wikipedia.org/wiki/Drug_tolerance
- tantalor 9y ago
  Tolerance generally does not affect the lethality of a drug.
  - ceejayoz 9y ago
    Hospice patients on morphine would strongly disagree. http://www.medscape.com/viewarticle/562216_3 http://www.medscape.com/viewarticle/562216_3 > Pharmacokinetic changes occur, for example, if the drug up-regulates the activity of a metabolic process that represents a major pathway for its elimination from the body. Enzyme induction results in a gradual reduction in plasma drug concentration while the daily opioid dose remains unchanged.
  - trendia 9y ago
    That's not entirely accurate in general. If the tolerance is the result of improved metablosim (as in alcoholism), then it could lead to decreased lethality.
  - kerkeslager 9y ago
    This isn't even the kind of claim that can be tested scientifically--there are too many different kinds of drugs. And I can think of many drugs where tolerance does affect lethality (opiates, alcohol). Where are you getting this information from?
richthegeek 9y ago
https://psychonautwiki.org/wiki/Caffeine#Toxicity_and_harm_potential https://psychonautwiki.org/wiki/Caffeine#Toxicity_and_harm_p... Assuming this kid is ~60kg (not fully grown) that's still at least 9000mg+ for an LD50. However, this seems like a huge number. I'm not much of a caffiene-user but know I get heart palpitations around 500mg and they sure feel like if I drank the same amount again I'd have serious problems.
- vorotato 9y ago
  You're assuming the kid wasn't dehydrated as well.

ceejayoz 9y ago

https://en.wikipedia.org/wiki/Drug_tolerance https://en.wikipedia.org/wiki/Drug_tolerance

tantalor 9y ago
Tolerance generally does not affect the lethality of a drug.
- ceejayoz 9y ago
  Hospice patients on morphine would strongly disagree. http://www.medscape.com/viewarticle/562216_3 http://www.medscape.com/viewarticle/562216_3 > Pharmacokinetic changes occur, for example, if the drug up-regulates the activity of a metabolic process that represents a major pathway for its elimination from the body. Enzyme induction results in a gradual reduction in plasma drug concentration while the daily opioid dose remains unchanged.
- trendia 9y ago
  That's not entirely accurate in general. If the tolerance is the result of improved metablosim (as in alcoholism), then it could lead to decreased lethality.
- kerkeslager 9y ago
  This isn't even the kind of claim that can be tested scientifically--there are too many different kinds of drugs. And I can think of many drugs where tolerance does affect lethality (opiates, alcohol). Where are you getting this information from?

richthegeek 9y ago

https://psychonautwiki.org/wiki/Caffeine#Toxicity_and_harm_potential https://psychonautwiki.org/wiki/Caffeine#Toxicity_and_harm_p... Assuming this kid is ~60kg (not fully grown) that's still at least 9000mg+ for an LD50. However, this seems like a huge number. I'm not much of a caffiene-user but know I get heart palpitations around 500mg and they sure feel like if I drank the same amount again I'd have serious problems.

vorotato 9y ago
You're assuming the kid wasn't dehydrated as well.