Naively, I feel like the same could be said about appliances, or kitchen items, or software, or food, or vehicles, or ... "Significant safety issue" seems both

Naively, I feel like the same could be said about appliances, or kitchen items, or software, or food, or vehicles, or ... "Significant safety issue" seems both poorly defined, and doesn't address the rate of incidence or the conditions necessary to create that issue. Many drugs have safety concerns when not used correctly, for example. Or in small populations.