(In the U.S.,) It's government funding and research that turns up most novel drugs (as opposed to tweaking existing formulae and mechanisms). And, there needs

(In the U.S.,) It's government funding and research that turns up most novel drugs (as opposed to tweaking existing formulae and mechanisms). And, there needs to be government funding (e.g. to an independent academia) and research that follows and studies the commercial as well as research lives and implementations of these drugs.