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Nevertheless, it is long being observed that for example in cancer most mutations are passenger mutations. And this is true even more if they come from non-codi
by patall 9y ago
Nevertheless, it is long being observed that for example in cancer most mutations are passenger mutations. And this is true even more if they come from non-coding regions.
Honestly, I am a bit surprised that you claim to have a bioinformatics background and are surprised about somatic variants. I mean, they are observed everywhere in NGS (and used on a daily basis for tracking pluripotent stem cell clonality and other things), there is not much surprising about it anymore.
- jboggan 9y agoMy unfinished PhD dissertation was about the topological differences in metabolic pathways expressed by various cancer cell lines in contrast to healthy tissue as a means of targeting metabolic "choke points" for future drugs - I'm not surprised about the existence of somatic variants but I am looking back and realizing how many of us were taking the uniformity of our systems for granted. Even when modeling the differences in a rapidly mutating cancer we always treated the variants as collections of discrete mutations that were uniform across the cluster. Then again this was ten years ago and you couldn't even think of sequencing enough lines to get at a cellular resolution. This really makes me want to pick that back up.