2 ms·
https://www.nature.com/articles/ncomms12484 https://www.nature.com/articles/ncomms12484 the more closely you look, the more obvious it becomes that this is the
by apathy 9y ago
https://www.nature.com/articles/ncomms12484 https://www.nature.com/articles/ncomms12484
the more closely you look, the more obvious it becomes that this is the rule rather than the exception. I would be somewhat surprised if children have functional mutations rampant between neurons, and I suspect that some fraction of this is artifactual. But I have no doubt (does anyone?) that some degree of somatic mosaicism is the rule. About the only cells that tend to hang around much longer than neurons are blood stem cells, and as soon as you look closely at those, it's all but unavoidable.
- apathy 9y agoGod damn it, that Science paper is piss weak even for a Science paper. It's yet another consortium advertisement. Meanwhile mapping of somatic mutations in blood progenitors has been happening for a decade.
- patall 9y agoThis exactly. Somatic variants are one of the most common things around. I always wonder why HN will almost never upvote a general informatics research article instead of a good review and with other fields of research it is the other way around where a review would be much better suited.