> It doesn't mean we can't compute with them, nor that the variation is useful or relevant. This is pretty much my understanding of it as well. We can expect

> It doesn't mean we can't compute with them, nor that the variation is useful or relevant. This is pretty much my understanding of it as well. We can expect that, even though we're now at the point of being able to appreciate the minute differences in sequence from cell to cell, almost all changes will have no significant effect on phenotype. However, in aggregate, on the scale of tissues, the could be some interesting effects? But I doubt it.