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Nobody ever said that all cells share 100% of DNA in the sense you're implying. It's obvious that DNA undergoes dynamic processes, some of which will result in
by matt4077 10y ago
Nobody ever said that all cells share 100% of DNA in the sense you're implying. It's obvious that DNA undergoes dynamic processes, some of which will result in lasting differences. The accumulation of errors is the basic mechanism for cancer, which has been recognised for decades.
But it was previously thought that such differences were detrimental to function (and health). There were some mechanisms for modifying cells' DNA, collectively known as "epigenetics", but these were reversible, at least in principle.
This adds another dimension of complexity, which biology already had plenty of. My favourite is the double- or triple-coding DNA: because DNA is read in triplets, there are three possible reading frames. Some organisms have evolved DNA that produces entirely different, but independently useful proteins on two or even all three reading frames of the same DNA. Talk about efficiency...
- patall 10y agoDo you have any links for the last paragraph? I know that there can be two gene encoded in reverse in bacteria but have no knowledge of any frame-shifted translations? About the second paragraph: well, it was not really thought that differences are always detrimental to health, and there is quite a number of variant prioritization tools out there that try to find those variants that are causal compared to all the silent/no-effect mutations (mostly for comparing humans but also somatic).