My guess is that he's talking about the responsibility of technologists because they are rolling out Windows 10 S, which is a step towards leaving behind Win32,

My guess is that he's talking about the responsibility of technologists because they are rolling out Windows 10 S, which is a step towards leaving behind Win32, an "unsafe" API that is heavily invested in by their core programmer base. That and they go on to show technology that can be used ways that could cause privacy concerns.