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(on my phone right now) Hasn't this been known for a while now? (with COX-2 NSAIDs specifically, like Advil). Even the standard book "The Biology Of Cancer" (2

by noam87 9y ago

(on my phone right now) Hasn't this been known for a while now? (with COX-2 NSAIDs specifically, like Advil). Even the standard book "The Biology Of Cancer" (2014) mentions it in passing in one of the later chapters. I believe there's even been trials where NSAID is applied topically during biopsy, reducing chance of mets. If I recall correctly, suspected mechanism is some sort of correlation between COX-2 inhibition and decreased expression of CTLA4/PD-1. It's kind of sad, but it seems that too often vital lines of research sit on university shelves for years before anything practical is done about it :/ (disclaimer: not an expert; just guy with cancer.)

dmichulke 9y ago
> Even the standard book "The Biology Of Cancer" (2014) mentions it Is this book ok for people with other backgrounds or does it require a good foundation in medicine or biology? And could a programmer (that knows how to learn) deal with it without spending months on research? Thanks and all the best wishes!
- noam87 9y ago
  um some parts are more high-level than others, but a lot would be gibberish. Familiarity with the contents of e.g "Molecular Biology Of The Cell" would greatly increase your experience. -- That book is big and exhaustive (and expensive), a focused intro to the same material is MIT "Introduction To Biology" on EDx! It's an amazing course! The book and MIT course also give a good enough conceptual intro to the chemistry concepts you need too. Obviously the rabbit hole goes deeep tho... people spend lifetimes scratching the surface.
jjtheblunt 9y ago
There's documentation of firocoxib (a partially selective COX-2 inhibitor used in veterinary medicine) with efficacy against osteosarcoma, for instance.
ajnin 9y ago
NSAID: Nonsteroidal Anti-Inflammatory Drug
killjoywashere 9y ago
Erm... that's actually a great book. I'm part-way through it, but set it down a while back because somewhere around chapter 10 I felt like I was up against the law of diminishing returns. If you could happen to get me a page reference, I'd appreciate it.
- deleted 9y ago
  [deleted]

by noam87 9y ago

dmichulke 9y ago

> Even the standard book "The Biology Of Cancer" (2014) mentions it Is this book ok for people with other backgrounds or does it require a good foundation in medicine or biology? And could a programmer (that knows how to learn) deal with it without spending months on research? Thanks and all the best wishes!

noam87 9y ago
um some parts are more high-level than others, but a lot would be gibberish. Familiarity with the contents of e.g "Molecular Biology Of The Cell" would greatly increase your experience. -- That book is big and exhaustive (and expensive), a focused intro to the same material is MIT "Introduction To Biology" on EDx! It's an amazing course! The book and MIT course also give a good enough conceptual intro to the chemistry concepts you need too. Obviously the rabbit hole goes deeep tho... people spend lifetimes scratching the surface.

jjtheblunt 9y ago

There's documentation of firocoxib (a partially selective COX-2 inhibitor used in veterinary medicine) with efficacy against osteosarcoma, for instance.

ajnin 9y ago

NSAID: Nonsteroidal Anti-Inflammatory Drug

killjoywashere 9y ago

Erm... that's actually a great book. I'm part-way through it, but set it down a while back because somewhere around chapter 10 I felt like I was up against the law of diminishing returns. If you could happen to get me a page reference, I'd appreciate it.

deleted 9y ago
[deleted]