I was responding specifically to the vitamin D claim, since that was the evidence you presented to make your fairly-extreme claim (and one that I happened to ha

I was responding specifically to the vitamin D claim, since that was the evidence you presented to make your fairly-extreme claim (and one that I happened to have some personal knowledge about). Even in general though, I don't see why the only thing to optimize for is as much bioavailability as possible. People care about things like cost too. (Though this opinion of mine is a lot less strong than my reaction to your initial claim)