Yes, many mouses are doing that, you just have to check with the manufacturer (I had A4Tech and Bloody mouses having this feature). Unfortunately this is not t

Yes, many mouses are doing that, you just have to check with the manufacturer (I had A4Tech and Bloody mouses having this feature). Unfortunately this is not the case for all mouses of one company so while Logitech G600 have this, Logitech M705 doesn't. I found out that mostly gaming oriented mouses have that feature. As for my mouse I have shortcuts for different systems (Linux, MacOS, Windows) set on each layer. Companion utility is needed only for initial setup.