Tkinter: - Bindings to Tk (Tcl; cross-platform GUI toolkit). - Bundled with Python. - Easiest to use but has the least features. - Ugly on Linux and is diff

Tkinter: - Bindings to Tk (Tcl; cross-platform GUI toolkit). - Bundled with Python. - Easiest to use but has the least features. - Ugly on Linux and is difficult to theme. - Good choice for small applications if you only care about utility. PyQt (or PySide): - Bindings to Qt (C++; cross-platform GUI framework). - PyQt is GPL licensed and supports Qt 4 and 5. - PySide is LGPL licensed and supports Qt 4 (support for 5 is in development). - The pixel perfect purists dislike it on Windows and Mac. - Good choice for large applications where an almost native look is sufficient. PyGTK: - Bindings to GTK+ 2 which is obsolete. PyGObject: - Bindings to GTK+ 3 (C/GObject; cross-platform GUI toolkit). - Comparable to Qt. - I've heard Windows support isn't the greatest (this may be obsolete now). - I'm biased and perfer Qt over GTK on Linux. - Good choice for large applications where an almost native look is sufficient. wxPython: - Bindings to wxWidgets (C++; cross-platform GUI toolkit). - Comparable to Qt. - Uses native widgets on Windows and Max, uses GTK+ on Linux. - Good choice for large applications where a native look is required. Kivy: - GPU accelerated GUI framework. - Does not look native. - Good choice for graphically intense applications that do not need a native look. My recommendation is: - Small, utility program: Tkinter. - Large application: Qt (if an almost native look is sufficient). - Large application: wxPython (if a native look is required). - Graphically intense application: Kivy.