6 ms·
Scientists hope they've found a drug to stop neurodegenerative brain diseases
- blazespin 9y agoSeems to me it would be just straightforward to get a list of people taking trazodone for long periods and measure their rates of neurodegeneration versus the general population versus those taking ssris.
- gwern 9y agoDepression is repeatedly linked to changes in BDNF and neurogenesis, so you would probably just see greater neurodegeneration compared to healthy controls anyway. Post-marketing surveillance is hard to draw any causal conclusions from...
- woofyman 9y agoTrazodone is also used for sleep.
- pswenson 9y agoI think much more widely for sleep than depression.... it was originally an anti-depressent but had a nasty side-effect of making one very sleepy.
- randycupertino 9y agoTrazodone helps me for sleep, it's incredible. I'm out like a light and it's not addictive. If you have nighttime anxiety and stress-related sleep issues, it can be a godsend.
- msie 9y agoI have heard that it is addictive so I'm curious as to what your experience is when not taking it. No withdrawal symptoms at all?
- randycupertino 9y agoNope, zero addiction. I take it about 5x a week, generally have weekends off.
- mzs 9y agoalso used for anger issues
- mrfusion 9y agoIt's interesting to see a sleep drug that might prevent Alzheimer's. I recently found out that benedryl might cause it.
- blazespin 9y agoThat's why you compare against SSRIs
- Fuzzwah 9y agoMy current day job involves doing the tech behind a series of dementia related online courses. Awesomely, we just kicked off the latest running of our Preventing Dementia MOOC: https://mooc.utas.edu.au/courses/preventing-dementia-2017-03 https://mooc.utas.edu.au/courses/preventing-dementia-2017-03 I emailed this link to our academic team as I'm sure they'll get bombarded with people asking why they should make changes to their life style if there is a magical cure just around the corner....
- summerdown2 9y agoIs there a short summary anywhere of recommendations for life style changes that do benefit the fight against dementia? I don't have it currently, but I must admit the older I get the more the prospect concerns me.
- circlefavshape 9y agoThe MIND diet https://www.ncbi.nlm.nih.gov/pubmed/25681666 https://www.ncbi.nlm.nih.gov/pubmed/25681666 https://www.ncbi.nlm.nih.gov/pubmed/26086182 https://www.ncbi.nlm.nih.gov/pubmed/26086182
- Fuzzwah 9y agoHere's the tl; dr.... The major risk factor for dementia is ageing. Approximately 30% of dementia cases may be attributed to seven key modifiable risk factors: * Diabetes * Midlife hypertension * Low educational attainment * Physical inactivity * Smoking * Obesity * Depression
- atomical 9y agoI just enrolled. Thanks for posting this.
- elchief 9y agoDBM being https://en.m.wikipedia.org/wiki/Dibenzoylmethane https://en.m.wikipedia.org/wiki/Dibenzoylmethane I'm going to talk to my family whether we should gice this (and trazedone) to my dad
- deleted 9y ago[deleted]
- joelthelion 9y agoThis is great, but if I read the study correctly, it's only been tested in mice for now. So I wouldn't get my hopes too high for now (I'd estimate the chances of success at 5% or less at this point).
- eru 9y agohttps://www.gwern.net/Nicotine https://www.gwern.net/Nicotine suggests we already have a drug that works fairly well for some diseases.
- eveningcoffee 9y agoThis is a nice reading. The only problem I see with anything inhaled (that is to some limited extent promoted here) is that it without compromise contaminates the surrounding air and forces the the bystanders to involuntarily to consume the byproduct.
- drspacemonkey 9y agoThere's alternate delivery mechanisms for nicotine. I've been using a rather foul-tasting "mint" oral spray [0]. It tastes like mint-flavoured death, but it's good for a quick 1mg dose. [0] https://www.amazon.ca/Nicorette-69547-Quickmist-Duo/dp/B004VDQH5O/ref=sr_1_1?ie=UTF8&qid=1493073766&sr=8-1&keywords=nicorette+spray https://www.amazon.ca/Nicorette-69547-Quickmist-Duo/dp/B004V...
- eru 9y agoPatches work great for long term delivery. Mints or gum works for people who need a quick fix---that's mostly ex-smokers. Never-smokers can probably stick to patches. On the other hand: I hate cigarette smoke---but I'm only mildly annoyed by second-hand vaping fumes.
- gumby 9y ago
- ak39 9y agoNew studies indicate that sleep is an important factor in cleaning up protein junk built up in the brain during wakeful hours. I wonder if the "real" impact of trazedone is the improvement in sleep quality and therefore by extension an effective maintainer of neurological physiology.
- gumby 9y agoprion diseases too??? That's hard to believe.