Depends. Recently I spent a day measuring every permutation of calculation-related optimizations I could think of for a critical inner code path. Then I noticed

Depends. Recently I spent a day measuring every permutation of calculation-related optimizations I could think of for a critical inner code path. Then I noticed I'd lazily used one virtual call for convenience, which had been there since the prototype stage. The three minutes spent removing it was by far the biggest win that day.