5 ms·

Um, no, this is a mouse study adding evidence for a link across some heavily studied pathways. One of my advisers cloned Il-1 30 years ago, and MyD88 is a well-

Um, no, this is a mouse study adding evidence for a link across some heavily studied pathways. One of my advisers cloned Il-1 30 years ago, and MyD88 is a well-studied protein in lymphoplasmacytic lymphoma. They've been working on this for a long time. It's hard. This is a step. Like many before it. And many after it.

mirimir 10y ago
OK, then, a step.
crowbahr 10y ago
Thanks for level headed input. The majority of technological advancement is done by cautious, slow research not by frenetic leaps and bounds.
- RangerScience 10y ago
  "Euraka" moments are fiction; what you get instead is "Huh, that's funny" (afaik).
  - killjoywashere 10y ago
    Subparent that started this. Having had a eureka moment, they definitely exist. That said, it's still 1% inspiration, 99% perspiration. In my case, it's more like 0.00001% inspiration, and all the rest is perspiration.
- raspasov 10y ago
  Debatable. What about "the greatest" advancements?
  - jfoutz 10y ago
    A little from column A, a little from column B. Einstein worked on relativity for a decade, i think. Newton looks to have spent about 8 years sorting out calculus. A professor once said the Fourier transform was worked out over a couple of weeks in a French chateau accompanied by Fourier's lover. I've never found a source other than that prof's story though. For me, and i suspect most people, when i work on something hard, i have a lot of ideas. most of them suck. some of them are promising but kind of die on the vine. That one sweet answer though, that idea is memorable. i think it's memorable because of the weeks, months, or years spent validating the idea is good enough.
    - raspasov 10y ago
      I agree. Learning everything about something without getting too attached to any point of view makes big leaps forward possible.
hdhdhdhdjjj777 10y ago
So "this COULD BE huge" is accurate
gregw2 10y ago
Any idea if the skin inflammatory conditions here share a common cause with cold urticaria, allergy to cold? A family member gets skin rashes when exposed to freezers at the grocery store or the freezer at home.

mirimir 10y ago

OK, then, a step.

crowbahr 10y ago

Thanks for level headed input. The majority of technological advancement is done by cautious, slow research not by frenetic leaps and bounds.

RangerScience 10y ago
"Euraka" moments are fiction; what you get instead is "Huh, that's funny" (afaik).
- killjoywashere 10y ago
  Subparent that started this. Having had a eureka moment, they definitely exist. That said, it's still 1% inspiration, 99% perspiration. In my case, it's more like 0.00001% inspiration, and all the rest is perspiration.
raspasov 10y ago
Debatable. What about "the greatest" advancements?
- jfoutz 10y ago
  A little from column A, a little from column B. Einstein worked on relativity for a decade, i think. Newton looks to have spent about 8 years sorting out calculus. A professor once said the Fourier transform was worked out over a couple of weeks in a French chateau accompanied by Fourier's lover. I've never found a source other than that prof's story though. For me, and i suspect most people, when i work on something hard, i have a lot of ideas. most of them suck. some of them are promising but kind of die on the vine. That one sweet answer though, that idea is memorable. i think it's memorable because of the weeks, months, or years spent validating the idea is good enough.
  - raspasov 10y ago
    I agree. Learning everything about something without getting too attached to any point of view makes big leaps forward possible.

hdhdhdhdjjj777 10y ago

So "this COULD BE huge" is accurate

gregw2 10y ago

Any idea if the skin inflammatory conditions here share a common cause with cold urticaria, allergy to cold? A family member gets skin rashes when exposed to freezers at the grocery store or the freezer at home.