4 ms·
> It's not immediately obvious to me why a histone would have such antibacterial properties. > I'm not sure it is an 'of course' here - rather it might actuall
by sndean 10y ago
> It's not immediately obvious to me why a histone would have such antibacterial properties.
> I'm not sure it is an 'of course' here - rather it might actually be a lucky find while playing with the truly cool sounding 'dragon's blood'.
It's most likely a result of the method used to pick peptides out of the blood samples [0]. Histone peptides have lots of K/Rs, and the bait used to trap the peptides is tuned to pull out small peptides with >5+ (? IIRC) net positive charge. So, pretty sure it's a lucky find while sifting through lots of histone peptides, where something inhibits/degrades biofilm formation and helps wounds close.
[0] http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117394 http://journals.plos.org/plosone/article?id=10.1371/journal....