If your experience is in the field you want to go into, you should be able to work at those places without a degree in said field, but you may have to circumven

If your experience is in the field you want to go into, you should be able to work at those places without a degree in said field, but you may have to circumvent parts of the hiring process. Don't submit your resume to keyword-sifting online black holes. Network your way into an interview, even if you have to do it through recruiters (which should be your last resort). If your experience is not in the field you want to be in, regardless of whether your degree is, get that experience first. That may mean a few more years paying dues at entry level again. Once you've established yourself as competent in that field, go after the big players. Also, many places will accept a closely related degree as a substitute for a specific degree. For instance, a bachelors in electrical engineering will get your foot in the door for many programming jobs.