depends on which drug you're talking about? Psilocybin and LSD are remarkably non-toxic. There is no known overdose level for either of those, as far as I know,

depends on which drug you're talking about? Psilocybin and LSD are remarkably non-toxic. There is no known overdose level for either of those, as far as I know, and I've read quite a lot of the research. That's not to say that a huge dose would be psychologically safe or comfortable, just that I don't know of anyone suffering bodily harm as the primary action of taking either psilocybin or LSD.