3 ms·
It's not that only 2% _can_ vary, it's that each person has about 2% different from the reference genome (and that 2% is different for every single person).
by adenadel 10y ago
It's not that only 2% _can_ vary, it's that each person has about 2% different from the reference genome (and that 2% is different for every single person).
- TheSpiceIsLife 10y agoAnd only a small subset of that 2% is able to cause pathology pathology. So any diagnosic or risk predictive tests need only check those areas know to result in or increase the risk of pathology.
- adenadel 10y agoThat's not at all true. For rare, undiagnosed disease we have to sequence the entire genome in order to look for the causative variants. For well understood (common) genetic disease we have small panels, but to say that only a small portion of the genome is informative is not correct. Additionally, there is no way to know a priori which loci will have the variation without sequencing the entire genome.