2 ms·
> Not in this case; the main effect of deuteration is to slow the rate at which the active drug is metabolized and excreted. this reminds me of deuterating DMT
by zkms 10y ago
> Not in this case; the main effect of deuteration is to slow the rate at which the active drug is metabolized and excreted.
this reminds me of deuterating DMT (dimethyltryptamine) in order to fortify bonds that are targeted by MAO -- to avoid the need for pretreatment with a MAO inhibitor (a MAOI -- which tend to be nasty because of all their interactions)