Mostly Ruby vs Python, though I think that's a big distinction. Rails is Ruby's killer app, but Python has killer apps in many things, so if you want to integra

Mostly Ruby vs Python, though I think that's a big distinction. Rails is Ruby's killer app, but Python has killer apps in many things, so if you want to integrate something else (like Machine Learning for example) easily into your code, then Django (because it is Python which has a lot better support for ML) makes that so much easier.