4 ms·
That part of the analogy does persist. It is the feature. The gene drive doesn't just insert the change you want - it inserts the change, and the code to make
by jfarlow 10y ago
That part of the analogy does persist. It is the feature. The gene drive doesn't just insert the change you want - it inserts the change, and the code to make the change:
Wild type mosquito DNA: =================
Desired change to DNA: =============XX==
DNA encoding Cas9 and XX-Payload: =C9(XX)=
Gene Drivered Mosquito (before activation) (change to compiler): ====C9(XX)=============
Gene Drivered Mosquito (after activation) (change to login code): ====C9(XX)========XX===
------------------------------
A normal mosquito mating with a XX mutant mosquito:
Mother Gamete: -----------------
Father Gamete: -------------XX--
Mendelian fraction of children (and grandchildren) are either --, --/XX,, or XX/XX (if two chromosomal copies)
A normal mosquito mating with a Gene Drivered mosquito:
Mother Gamete: -----------------
Father Gamete: ---C9(XX)----XX--
All children: ====C9(XX)========XX=== (for all 'N' chromosomal copies)