There’s ~ 15K-20K diseases that we’ve classified. There’s 3.2Bn genetic base pairs. There’s just over 7Bn people. Maybe like 7M-20M people suffer from a dise

There’s ~ 15K-20K diseases that we’ve classified. There’s 3.2Bn genetic base pairs. There’s just over 7Bn people. Maybe like 7M-20M people suffer from a disease or even well below or above that. Finding someone at a given time in the exact modality that would be testable by a given trial is really hard. Genes are sets of base pairs. A lot of drug discovery is a situation where you have to test compounds empirically against a notion of a theory of a viable drug target. Some drugs may be efficacious, but they may kill you. Some genes may work in coalition with other genes, not at all, or against some genes. There's also the fundamental notion about the druggability of a disease. This article does a great job in outlining it: http://omicsomics.blogspot.com/2017/03/targets-drugability-revisited.html http://omicsomics.blogspot.com/2017/03/targets-drugability-r... There are no monstrously hard computational power problems in drug development that are waiting for mathematical brains to pursue. There are hard Empirical problems. Empirical problems are problems which require actual experiments to show resultant data.