4 ms·

There's Parmesus Vasalgel that is going through trials in the US, based on this tech. Also, a startup whose name I forget is developing the same kind of tech. T

by ph0rque 10y ago

There's Parmesus Vasalgel that is going through trials in the US, based on this tech. Also, a startup whose name I forget is developing the same kind of tech. They were part of YC Fellowship Batch 3.

ckastner 10y ago
The article mentions this, although it's not quite clear to me how they differ (and by how much). Parsemus apparently got started by licensing the technology from Guha, then developed its own solution inspired by that technology.
- 24gttghh 10y ago
  The tech in this article allow sperm through but damage the sperm. The Parsemus tech seems to block the tubes entirely.
  - tgtweak 10y ago
    Untrue, actually they both use the same system (and almost identical formulation). The difference being the focus on the FDA process and US market that vaselgel is taking, you can see the cleverly worded non-answer on their own FAQ, quoted below. They do "filter" the vasdeferentia and not block it. This is actually preferential as it can alleviate a small chance of pain or sperm granulomas after a vasectomy, also quoted below. Although Vasalgel and RISUG® are based on the same concept of using a polymer gel injected into the vas deferens, the formulations are not the same. And RISUG has been developed and tested in India over multiple decades, while Vasalgel is being developed in the United States to conform to the latest FDA and international codes of production and safety. And only a small percentage of men who have had a vasectomy experience chronic pain (1-2% according to the American Urological Association). Our current understanding of Vasalgel is that fluids can pass through the gel, but sperm cannot. This will likely reduce the incidence of back-pressure. Sperm granulomas are formed when the vas deferens is severed in a vasectomy and sperm leak into surrounding tissue. Since injection of Vasalgel does not involve cutting the vas deferens, this should not be an issue. Notice the non-answer below: Our understanding is that Vasalgel works by blocking or filtering out sperm. In the past, RISUG (a different product) was described as working by shredding sperm by an electrical charge process as they went past the contraceptive that lined the walls of the vas deferens. Vasalgel makes no such claims. https://www.parsemusfoundation.org/projects/vasalgel/vasalgel-faqs/ https://www.parsemusfoundation.org/projects/vasalgel/vasalge...
rory096 10y ago
>Also, a startup whose name I forget is developing the same kind of tech. They were part of YC Fellowship Batch 3. Contraline: http://contraline.com http://contraline.com

by ph0rque 10y ago

There's Parmesus Vasalgel that is going through trials in the US, based on this tech. Also, a startup whose name I forget is developing the same kind of tech. They were part of YC Fellowship Batch 3.

ckastner 10y ago

The article mentions this, although it's not quite clear to me how they differ (and by how much). Parsemus apparently got started by licensing the technology from Guha, then developed its own solution inspired by that technology.

24gttghh 10y ago
The tech in this article allow sperm through but damage the sperm. The Parsemus tech seems to block the tubes entirely.
- tgtweak 10y ago
  Untrue, actually they both use the same system (and almost identical formulation). The difference being the focus on the FDA process and US market that vaselgel is taking, you can see the cleverly worded non-answer on their own FAQ, quoted below. They do "filter" the vasdeferentia and not block it. This is actually preferential as it can alleviate a small chance of pain or sperm granulomas after a vasectomy, also quoted below. Although Vasalgel and RISUG® are based on the same concept of using a polymer gel injected into the vas deferens, the formulations are not the same. And RISUG has been developed and tested in India over multiple decades, while Vasalgel is being developed in the United States to conform to the latest FDA and international codes of production and safety. And only a small percentage of men who have had a vasectomy experience chronic pain (1-2% according to the American Urological Association). Our current understanding of Vasalgel is that fluids can pass through the gel, but sperm cannot. This will likely reduce the incidence of back-pressure. Sperm granulomas are formed when the vas deferens is severed in a vasectomy and sperm leak into surrounding tissue. Since injection of Vasalgel does not involve cutting the vas deferens, this should not be an issue. Notice the non-answer below: Our understanding is that Vasalgel works by blocking or filtering out sperm. In the past, RISUG (a different product) was described as working by shredding sperm by an electrical charge process as they went past the contraceptive that lined the walls of the vas deferens. Vasalgel makes no such claims. https://www.parsemusfoundation.org/projects/vasalgel/vasalgel-faqs/ https://www.parsemusfoundation.org/projects/vasalgel/vasalge...

rory096 10y ago

>Also, a startup whose name I forget is developing the same kind of tech. They were part of YC Fellowship Batch 3. Contraline: http://contraline.com http://contraline.com