For English, you probably want to check out Colemak. It does well on a very wide variety of measures of ergonomics (there is actually not a lot of agreement on

For English, you probably want to check out Colemak. It does well on a very wide variety of measures of ergonomics (there is actually not a lot of agreement on what makes a layout good, so take with a grain of salt), while also not being too different from QWERTY, and keeping the XCV keys in the same place.