3 ms·
Well, they need to make sure they are looking at the right type of data. I know it is blasphemous, but why not include the aneuploidy/chromosomal data as well?
by nonbel 10y ago
Well, they need to make sure they are looking at the right type of data. I know it is blasphemous, but why not include the aneuploidy/chromosomal data as well? These error rates appear to be much higher than point mutations, etc:
"Nevertheless, the rate of chromosome missegregation in untreated RPE-1 and HCT116 cells is 0.025% per chromosome and increases to 0.6 – 0.8% per chromosome upon the induction of merotely through mitotic recovery from either monastrol or nocodazole treatment ( Fig. 3 C ). These basal and induced rates of chromosome missegregation are similar to those previously measured in primary human fibroblasts ( Cimini et al., 1999 ). Assuming all chromosomes behave equivalently, RPE-1 and HCT116 cells missegregate a chromosome every 100 cell divisions unless merotely is experimentally elevated, whereupon they missegregate a chromosome every third cell division. Chromosome missegregation rates in three aneuploid tumor cell lines with CIN range from 0.3 to 1.0% per chromosome (Fig. 3 C ). Depending on the modal chromosome number in each cell line, these cells missegregate a chromosome every cell division (Caco2), every other cell division (MCF-7), or every fifth cell division (HT29)."
https://www.ncbi.nlm.nih.gov/pubmed/18283116 https://www.ncbi.nlm.nih.gov/pubmed/18283116
Many people claim that aneuploidy is found in nearly all cancer cells:
https://www.ncbi.nlm.nih.gov/pubmed/17046232 https://www.ncbi.nlm.nih.gov/pubmed/17046232
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443636/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443636/
https://www.ncbi.nlm.nih.gov/pubmed/10687734 https://www.ncbi.nlm.nih.gov/pubmed/10687734
- deleted 10y ago[deleted]