3 ms·
Here is another one, apparently we can get a drop of up to 99.5% just by switching to lab tests from clinical diagnosis: "Indeed, an average of only 100 cases o
by nonbel 10y ago
Here is another one, apparently we can get a drop of up to 99.5% just by switching to lab tests from clinical diagnosis:
"Indeed, an average of only 100 cases of measles are confirmed annually [32], despite the fact that >20,000 tests are conducted [28], directly suggesting the low predictive value of clinical suspicion alone."
http://jid.oxfordjournals.org/content/189/Supplement_1/S185.full http://jid.oxfordjournals.org/content/189/Supplement_1/S185....
I just don't think these alternative explanations have been investigated very well, and the blinded RCT (vs placebo) is missing. Another thing, the various proxies for "vaccine success" they use do not correlate with each other...
"Our data demonstrate that regression analysis shows only limited correlation between NT results and the ELISA values. This is in agreement with other reports [4]. Similar limitations in the correlation were also reported for other viruses like Cytomegalovirus (CMV) [10]. In case of the gamma globulin samples, the low correlation might reflect the wider spectrum and heterogeneity of the involved or measured measles antibodies."
http://www.ncbi.nlm.nih.gov/pubmed/17308917 http://www.ncbi.nlm.nih.gov/pubmed/17308917
- mattkrause 10y agoThat's not a sensible interpretation of that measles data. Since measles is very contagious, there's a lot of effort putting into identifying and isolating cases. This necessarily involves screening many cases where the disease is only weakly suspected. On top of that, the current protocols cast a really wide drag net. Australia, for example, tests every susceptible patient who shared a waiting room with a measles patient, as well as those who entered less than two hours after the index case left. In a busy hospital or practice, this could be a lot of children. Thus, the high ratio of tested to confirmed cases doesn't mean doctors are bad at diagnosing measles; they may just be cautious.
- nonbel 10y agoSo how large do you think such a diagnosis effect may be? That other paper reported only 7% of clinical diagnoses were lab positive for measles in Singapore. And yet another effect to deal with is that people used to spread measles on purpose: “Before the introduction of measles vaccines, measles virus infected 95%–98% of children by age 18 years [1–4], and measles was considered an inevitable rite of passage. Exposure was often actively sought for children in early school years because of the greater severity of measles in adults.” http://jid.oxfordjournals.org/content/189/Supplement_1/S4.full http://jid.oxfordjournals.org/content/189/Supplement_1/S4.fu... I think for these reasons it is clear the effectiveness of measles vaccines has been overstated, it is only a matter of how much.