3 ms·
Thanks, it looks like this one was done after I was searching. This study doesn't really have the outcomes we need to measure though. There is no placebo group,
by nonbel 10y ago
Thanks, it looks like this one was done after I was searching. This study doesn't really have the outcomes we need to measure though. There is no placebo group, they didn't check for measles diagnoses (by doctors who didn't know whether they were vaccinated), and they only measured antibody levels for 1.5 months after 1 vaccine dose in children 12-23 months old (ie before going to school when exposure usually occurs).
Unfortunately, I really don't think this study offers us anything about whether "vaccines work". You can see that the main concern is whether doctors are much more likely to diagnose measles when they do not believe a vaccination occurred, and whether introduction of the lab tests made the diagnostic definition more stringent:
“This was not a blind study, since the investigators knew which children had received measles vaccine. It seems probable that the occurrence of so much ‘measles-like’ illness in the vaccinated children was a reflexion of the difficulty in making a firm diagnosis of measles in the African child at one visit.”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134550/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134550/
“A likely reason for this is that the case may have been misdiagnosed as a non-specific viral illness. Measles has become relatively uncommon in Singapore with two decades of widespread measles vaccination, and especially after the second dose policy was implemented in 1998. Many primary care doctors may not even see a single case of measles in a year. This makes diagnosis more difficult.
[...]
As only approximately 7% of the clinically-diagnosed cases of measles reported locally turned out to be measles by laboratory testing, there is a need for laboratory confirmation of measles to avoid misidentification of cases and improve disease surveillance.(2)”
http://www.ncbi.nlm.nih.gov/pubmed/17609829 http://www.ncbi.nlm.nih.gov/pubmed/17609829