4 ms·

Target p53 no thanks.

• vajrabum 10y ago
  Care to amplify that comment a bit for those of us in the cheap seats?
  • danbruc 10y ago
    Wikipedia has quite a bit of information about p53. [1] It seems to have an important role as a suppressor for cancer. So maybe the comment was referring to that, you probably don't want to mess that up. [1] https://en.wikipedia.org/wiki/TP53 https://en.wikipedia.org/wiki/TP53
• plaguuuuuu 10y ago
  And I have my next grindcore song title
• notsosmart 10y ago
  When apoptosis fails, it's might be because p53 binds to foxo4 and gets stuck in the nucleus which prevents the p53 from getting to the mitochondria. In the experiment p53 in the paper, p53 unbound from foxo4 in the nuclease and bound to foxo4-dri and successfully flowed down the mitochondria so apoptosis could occur.