3 ms·
> “TMEM106B begins to exert its effect once people reach age 65,” Genes does not work that way. Unless a specific protein and particular pathway are identified
by lngnmn 10y ago
> “TMEM106B begins to exert its effect once people reach age 65,”
Genes does not work that way. Unless a specific protein and particular pathway are identified, and the effect of mutated protein is validated, this is mere a speculation.
- ajross 10y agoThat's only colloquial, not wrong. The corrolation between this gene and the observed effects exists only after age 65. I don't see that this precision would change much in the way the intended reader is going to interpret it. Something about the presence of this gene[1] is causing early frontal cortex degeneration after age 65. [1] Unlike lots of other situations in medicine, the direction of causality is known here: this gene obviously can't be the result of some other age-related driver of degeneration. Genes do not work that way, heh.